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BIBW 2992(Tovok)肺癌新药

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228746 190 平安! 发表于 2010-10-1 21:24:14 |
张玉强  初中一年级 发表于 2013-8-22 20:54:14 | 显示全部楼层 来自: 北京
2个月2292就耐药,有点担心!
张玉强  初中一年级 发表于 2013-8-22 20:55:08 | 显示全部楼层 来自: 北京
谁知道,YL2992与正版的阿法替尼有多大差别?
张玉强  初中一年级 发表于 2013-8-22 22:12:34 | 显示全部楼层 来自: 北京
找找中药,可能不到调理有用,病情有稳定。
岁月匆匆  小学六年级 发表于 2013-9-6 14:35:20 | 显示全部楼层 来自: 安徽马鞍山
一定要做好准备,一是做好对副作用的应对;二是做好YL版的混装;三是要多了解靶向药的知识;四是多备几种靶向药,感谢憨叔和老马!
老马  博士一年级 发表于 2013-9-11 01:19:52 | 显示全部楼层 来自: 浙江温州
LUX-LUNG 4
The phase II LUX-LUNG 4 trial gives further support to the idea that afatinib may be a good option for patients who develop that T790M resistance mutation following treatment with other TKIs. Researchers led by Nobuyuki Katakami, MD, PhD, of Kobe City Medical Center General Hospital in Kobe, Japan, treated 62 patients who were EGFR-mutation positive in the primary tumor with afatinib at 50 mg/day. Fifty-one of the patients (82.3%) qualified as having acquired resistance to erlotinib and/or gefitinib.

Of the 61 patients who were evaluable, five (8.2%) had a confirmed objective response to afatinib. The median progression-free survival was 4.4 months, with a median overall survival of 19 months. Among the afatinib-related adverse events, all patients experienced diarrhea and most (91.9%) had rash/acne; 29% of patients had an adverse event that led to discontinuation of the drug.

“The results of our trial demonstrated modest but noteworthy activity of afatinib in this difficult-to-treat population,” the authors wrote. They noted that further trials are now ongoing, including one phase IB trial testing the combination of afatinib and cetuximab(Drug information on cetuximab) in a small number of patients. “There is an increasing need to develop new molecular targeted agents that address the issue of resistance to erlotinib and/or gefitinib in patients with NSCLC who initially respond to treatment and then subsequently progress.”

点评

可能试验选择了特定人群(Subgroup)=EGFR有突变的,效果是比较好的;论坛(包括"奇迹")使用2992有效率似乎差些。  发表于 2013-11-19 03:36
个人公众号:treeofhope
cttoday  小学一年级 发表于 2013-11-18 22:03:36 | 显示全部楼层 来自: 北京
请问哪里有卖2992
1548588601  初中一年级 发表于 2013-11-22 09:15:05 | 显示全部楼层 来自: 黑龙江大庆
学习了很多,收获很多。
1548588601  初中一年级 发表于 2013-11-22 09:16:16 | 显示全部楼层 来自: 黑龙江大庆
目前,美国和台湾都有正版的,澳门年底能审批下来。
累计签到:2 天
连续签到:2 天
[LV.1]初来乍到
changqiao  初中三年级 发表于 2014-3-2 07:15:46 | 显示全部楼层 来自: 天津
肺腺癌IV期,请问哪能买2992,就急呀,知到的朋友给指条路好么!!!!跪谢。

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