这是一个低剂量CTX+IL2维持化疗有效小细胞肺癌的实验，实验结果显示维持治疗没有优势，只有那些接受预防性放疗的病人PFS、OS有延长趋势。但我认为这个实验的用药方式有问题，维持治疗在于低剂量而持久，这个实验设计的剂量不低，所以用药时间就不能持久，每次用药间隔差不多一个月呢，如何实现持续免疫提升和抗血管生成？
http://meetinglibrary.asco.org/content/94245-114
Background: huKS-IL2 immunocytokine is a humanized antibody specific for EpCAM, fused at its Fc end to two molecules of IL2. Results of a phase 1b study of huKS-IL2 plus low-dose CTX, and preclinical data, provided a rationale to evaluate this combination in SCLC, which is often EpCAM-positive.
Methods: Patients (pts) with ED-SCLC responding (PR/CR) to 4 cycles of first-line Pt-based chemotherapy were randomized 1,5:1 to receive huKS-IL2/CTX or best supportive care (BSC). Pts in the huKS-IL2/CTX arm received six 21-day cycles of CTX 300 mg/m2 on day (d) 1, and 1.5 mg/m2/d huKS-IL2 on d2–4, followed by 21-d cycles of CTX on d1 and huKS-IL2 on d2 until progression. Pts were stratified for prophylactic cranial irradiation (PCI) and response to chemotherapy. Primary endpoint was PFS rate at 6 months (mo). Secondary endpoints included OS rates at 12 and 18 mo from start of Pt-based chemotherapy, median PFS and OS, safety, and immunogenicity.
Results: 108 pts (64 huKS-IL2/CTX arm, 44 BSC arm) were randomized and treated. Baseline characteristics were balanced between arms; however, higher % of males (75 vs 61.4%) and of ECOG PS 0 (45.3 vs 38.6%) were observed in the active arm. Median age was 61.7 (32; 81) and 59.2 (45; 74) years in the active and BSC arm, respectively. Most pts were in PR at randomization (2 pts – 1 in each arm – had CR). PCI was used in 15 (23.4%) and 11 (25%) pts in the active and BSC arm, respectively. No significant differences in PFS or OS were observed in the active vs BSC arm: PFS rate was 6.4 vs 12.2%; median PFS was 1.5 vs 1.4 mo; OS rates at 12 and 18 mo were 52 vs 61% and 24 vs 29%, respectively; median OS was 12.3 vs 14.1 mo. One PR (45% reduction vs randomization baseline) was observed in the active arm. In a subset of pts who received PCI, median PFS was 1.7 vs 1.5 mo, median OS 21.5 vs 14.3 mo in the active vs BSC arm, respectively. AEs observed more frequently in the active arm were flu-like symptoms, rash, hypotension, lymphopenia, LFT and creatinine elevations; all Grade 3/4 AEs related to huKS-IL2 were reversible/manageable.
Conclusions: HuKS-IL2/CTX was well tolerated, but showed no benefit in pts with ED-SCLC in PR/CR after chemotherapy. A trend for improved PFS and OS was observed in pts who received prior PCI.
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乳腺癌或可被“治愈”，乳腺疫苗5年0
作者：淼淼
疫苗，可以说是人类最伟大的发现之一。
从1976年全球第一款牛痘疫苗问世以
每天吃这种药，乳腺癌风险有望降低42
乳腺癌前病变，包括非典型导管增生（ADH）、小叶原位癌（LCIS）和导管原位癌（DCIS）
忆五年~我和父亲的抗癌历程，爸爸走
2017年的9月6日，我的父亲在天津市第四中心医院，因为长期的后背疼痛经过医院
求助 K药和替雷利珠如何选择
父亲9月刚查出非小细胞低分化癌伴随左肾上腺和第10胸椎转移PDL1高表达(TPS=90%) SMARC
官方不推荐作为肺癌筛查的“肿瘤标志
作者：小莱
体检时，“肿瘤标志物”这个名字直白的检查总能引起大家的兴趣，检查报告
显身卡
