发给老马备查:
7 H3 g1 Z5 ^. e- Z9 V* Q滴水察海(69304838) 15:23:23
1 J7 a" Q) I1 ]. ]0 R老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
" D$ [/ K6 F6 S( ~: k吉非替尼和S-1连用的依据
( G* g6 V, N# w3 rGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
2 G& V. s' y$ t3 p' ^: _是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达$ I. Z' g6 u) Z( E8 Y
这样是不是推理出,耐药后,可以用S-1和培美了?, Q, t0 a! U+ A# t+ S+ Q
结论:
- ?' H) P3 M8 H& W如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |