发给老马备查:4 M5 l( d, d7 ~. [; R; h
滴水察海(69304838) 15:23:23" n* ^! Y0 w3 Z8 a
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱& D; d5 {5 w, B! ?" D- U; ?
吉非替尼和S-1连用的依据
. _3 B6 o1 n( n qGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
) S& H; [$ [/ h0 u1 K6 ]是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
, r$ j1 F! b, ?$ p5 C6 ^, s这样是不是推理出,耐药后,可以用S-1和培美了?
1 x) H, S; K* H结论:
5 l) N0 h5 u2 G1 A8 `0 R( E如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |