发给老马备查:# l, ?" K$ Q* y* S+ J
滴水察海(69304838) 15:23:23
1 j5 n9 ~! u# j+ M9 C, n' h老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
) _* M: f% |; H+ m7 p吉非替尼和S-1连用的依据* n- _1 ?' W0 e# U( [+ o* w+ q
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.0 }: h6 _/ [. ?' O* }
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达2 H( ?. B3 m9 h/ S& i6 a: w( G( L
这样是不是推理出,耐药后,可以用S-1和培美了?
1 ?9 t0 y7 s- o4 K" t4 Y结论:% h4 s; T# B. \; D
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |