发给老马备查:# i) {. d* j, G" l& V" e+ A
滴水察海(69304838) 15:23:23
r8 M$ w+ ^5 z7 u: U老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱* h& L+ J- q% K% R( [
吉非替尼和S-1连用的依据7 t( G6 N' [& ^2 @
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.9 v) n, S* N' R% t3 T
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
, j+ X- k8 [ H; B这样是不是推理出,耐药后,可以用S-1和培美了?
B$ S/ W" {/ ^5 p* i/ c- ?结论:
s$ l9 Q8 H, C% s3 M$ Z如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |