发给老马备查:, j5 U% P0 U9 m7 ?
滴水察海(69304838) 15:23:23+ s) {! A: N2 `3 @1 l* b7 ^/ X& ?
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
7 s& s4 B/ h) ^& q/ _, s吉非替尼和S-1连用的依据
$ v$ x) B6 C( w3 G8 R( J# ZGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
, U" A/ s- Y) L! A" P是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达) Z. ]% K2 C7 B5 S' K% n7 ~9 ~
这样是不是推理出,耐药后,可以用S-1和培美了?
' j& h, P6 d" _. \1 f+ S结论: L2 p3 n7 h# b; o
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |