发给老马备查:" J! H* n" _8 |
滴水察海(69304838) 15:23:23
" u) C; r* e) S& P! @老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱/ y* j- B1 U& W2 j& `! n
吉非替尼和S-1连用的依据. V2 }% _, z" x* K
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro., @% f* Z9 z( H9 Y4 D P& F5 Q C
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
( j* A9 P# {2 A8 @2 k- K8 b3 w这样是不是推理出,耐药后,可以用S-1和培美了?
# X- W! G$ a3 g/ l% x& [结论:
- K8 i h* C: A如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |