发给老马备查: C) ]# J" l$ I$ S7 s
滴水察海(69304838) 15:23:23
( l r# Z# V9 k% \老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱7 [/ C9 w3 _; k Z5 x
吉非替尼和S-1连用的依据( | G) O& I$ l, W) q$ w* s
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
1 V" Z* R3 w! Y0 y是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
) R% ]; A6 y7 u+ X, `这样是不是推理出,耐药后,可以用S-1和培美了?2 q0 G) |5 _. o _* ?
结论:
$ j9 B# z% B# i! q6 a. ~; I如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |