二甲双胍可能还可治肺癌

uzhh · 发表于 2011-11-13 23:36:17

我个人认为既然吃了二甲双胍，就定期监控一下血糖，包括空腹血糖和餐后2小时血糖。

SG610E · 发表于 2011-11-29 14:10:36

谢谢，收藏了。

emma · 发表于 2011-12-6 00:14:08

憨豆精神发表于 2011-1-19 21:41

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我已经开始二甲双胍了。

请问憨叔，这个药吃了后怎么样？感觉有效吗？

phpinfo · 发表于 2012-6-18 20:36:55

对啊这个效果如何呢给大家说说吧？

痛恨癌症 · 发表于 2012-6-19 08:46:51

Protective effect of metformin in lung cancer patients. Print this page

Sub-category:
Prognostic Factors

Category:
Tumor Biology

Meeting:
2009 ASCO Annual Meeting

Session Type and Session Title:
This abstract will not be presented at the 2009 ASCO Annual Meeting but has been published in conjunction with the meeting.

Abstract No:
e22063

Citation:
J Clin Oncol 27, 2009 (suppl; abstr e22063)

Author(s):
B. Gagnon, M. Roseman, G. Kasymjanova, N. MacDonald, H. Kreisman, D. Small; McGill University, Montreal, QC, Canada; SMBD-Jewish General Hospital, Montreal, QC, Canada

Abstract Disclosures

Faculty and Discussant Disclosures

Annual Meeting Planning Committee Disclosures

2009 Annual Meeting Proceedings Part I Errata

Abstract:

Background: Over the past decade, dozens of studies have shown that metformin not only decreases mortality in diabetics, it also significantly reduces CRP and reduces the risks of cancer in rodent and human cell lines. We report on the survival of lung cancer patients concomitantly exposed to metformin in our community-based program. Methods: 850 patients undergoing treatment from a prospectively collected pulmonary oncology database of the SMBD-Jewish General Hospital over an 8-year period were analyzed. Pilot observational study of survival was performed using Cox regression model. The factors that were included in the model were age, gender, stage, histology and metformin use. Results: 850 patients (F: M=375:475; mean age of 66) were diagnosed since 2000 and followed in pulmonary oncology outpatient clinic for NSCLC. 523 (62%) of those patients were diagnosed with adenocarcinoma; 488 (57%) were stage IIIB with pleural effusion/IV. 79(9%) patients were receiving treatment with metformin for their comorbid type 2 diabetes. The Cox regression analysis demonstrated that age, gender, stage and use of metformin were significant prognostic factors for survival. The use of metformin is associated with a 37% (HR 1.37; CI 1.01-1.84) (p=0.039) increase in survival. Conclusions: Thus, the result obtained from our model suggests that use of metformin may be associated with better survival of lung cancer patients. As this is a pilot study, we will consider alternative explanations.

liangqj · 发表于 2012-6-19 15:24:33

有用吗？学习中

憨豆精神 · 发表于 2012-6-19 15:42:32

不要把这些陈旧的信息当宝了。
那时候靶向药只有四种，肺癌两种，加上多吉美和索坦，只好胡乱找些所谓抗癌的偏方尝试。老外其实也和中国人一样，非常希望走捷径，各种廉价的易得的所谓抗癌偏方满天飞：低剂量纳曲酮、低剂量阿司匹林、低剂量二甲双胍、大剂量维生素C、大剂量姜黄素、大蒜精、青蒿琥脂、苏打水、二氯乙酸钠……你如果想试，又有命试，可以一年几年十年试不过来，还未计中国人的癞蛤蟆、红豆杉、核桃树皮、海参、斑蝥、各种“抗癌”中药方、几丁聚糖、胸腺肽、灵芝粉……还有日本人的五行蔬菜汤+尿……
实际上，除了二氯乙酸钠还勉强有点抗癌的作用，其他全部都是胡闹。看看今天的靶向药，越来越多，越来越好，何必再在那些不着边际的偏方里折腾？
说回二甲双胍，吃了除了肚子饿低血糖，还能有什么结果？是不是所以吃二甲双胍的糖尿病人都不会长癌，长了也会消除？
不过，我原谅我自己当初的胡乱尝试，因为那时实在没多少种靶向药，至少我还没遇上2992和凡德他尼和阿西替尼这些优秀的靶向药。