关于逆转4002耐药，老马发过一篇理论型的文章（4002+AZD6244）

下载了老马的4002耐药机理的文章，其中的结论就是Findings from our study show that the combination of WZ4002 and an allosteric MEK inhibitor may be an effective strategy not only to treat drug-resistant cancers (Figs. 2B , 3C ,and 4G and H ) but also to prevent the emergence of drugresistant clones ( Fig. 4I and J ). Coupled with our prior studies showing that WZ4002 alone can prevent the emergence of EGFR T790M in model systems, the combination of WZ4002 and a MEK inhibitor may be a particularly effective therapeutic strategy for EGFR -mutant NSCLC and should be tested in a clinical trial ( 13 ).
上文大致的的意思就是4002联合MEK类抑制剂（目前就6244），所以想看看论坛内有谁用过这个方案

http://www.yuaigongwu.com/forum. ... &extra=page%3D2

AZD6244+BEZ235组合针对吉非替尼耐药非小细胞肺癌移植瘤模型

貌似是一个可行的方案

后悔上学没学好

6244是否也可以逆转或者延长9291耐药？

新知识，学习了！

理论上可以延长9291耐药